Advanced Lipid-Based Drug Delivery Systems: Solid Lipid Nanoparticles & Nanostructured Lipid Carriers
“As featured in Drug Development & Delivery Magazine”
INTRODUCTION
The utility of functional lipids in enhancing the dissolution and bioavailability of poorly water-soluble actives is well known. The use of lipid-based drug delivery systems in pharmaceutical product development is increasing due to the versatility of functional lipid excipients and the compatibility of these excipients with liquid, semi-solid, and solid pharmaceutical dosage forms.1 In addition to solubility and bioavailability enhancement, functional lipids have been employed in a multitude of broad-based excipient applications, including matrix and encapsulated sustained release, tablet lubrication, tablet dry binding, and as pharmaceutical unit operation processing aids.2-5 Although the applications of functional lipids as excipients and drug delivery systems for the pharmaceutical industry has been understood for quite some time, novel features of functional lipids continue to be discovered and employed in ever-emerging drug delivery systems. Two examples of innovative lipid-based nanoparticle drug delivery technologies are solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs). SLN and NLC formulations maintain the enhanced solubility benefits of traditional liquid colloidal carrier drug delivery systems, but provide several additional benefits, such as increased chemical stability for the Active Pharmaceutical Ingredient (API), potential for sustained release, targeted delivery, and lymphatic delivery, which allows for the avoidance of first-pass metabolism as well as lymphatic targeting.6
About the Author:
Dr. John K. Tillotson research areas include functional lipids, SEDDS development, and direct-compression tableting. He joined ABITEC Corporation in 2015, and currently serves as the Pharmaceutical Technical Business Director for the Americas, responsible for business development and product technical support in the US, Canada, and Latin America. He has extensive experience in the development of solid oral dosage forms, including the development of multiple direct compression, drug delivery systems, and formulations. He earned his BS in Pharmacy (Ferris State University, MI) and his PhD in Industrial Pharmacy (University of Cincinnati, OH). He can be reached at (614) 429-6464 or [email protected].
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Amanda Coulter, Manager: Marketing Research and Communications
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