Manufacturing SEDDS with ABISORB-DC White Paper Request
Manufacturing of 10mg loratadine self-emulsifying drug delivery system (SEDDS) tablets by direct compression with ABISORB-DC™ and the ABISOL™ Emulsion Preconcentrate Kit
John Tillotson R.Ph., Ph.D., Donald Kelemen Ph.D.
10mg loratadine SEDDS were successfully manufactured with ABISORB-DCTM and ABISOLTM 2 by direct compression on a rotary tablet press, employing standard pharmaceutical manufacturing equipment.
- Tablets exhibited suitable robustness, as demonstrated by both tablet hardness and friability.
- Tablets were both weight uniform and passed the uniformity of dosage unit requirements, with regard to loratadine concentrations.
- Tablets exhibited complete drug release.